REPROGRAMMING ANTITUMOR IMMUNITY AGAINST CHEMORESISTANT OVARIAN CANCER BY A CXCR4 ANTAGONIST-ARMED VIRAL ONCOTHERAPY

Reprogramming antitumor immunity against chemoresistant ovarian cancer by a CXCR4 antagonist-armed viral oncotherapy

Ovarian cancer remains the most lethal gynecologic malignancy owing to late detection, intrinsic and acquired chemoresistance, and remarkable heterogeneity.Here, we explored approaches to inhibit metastatic growth of murine and human ovarian tumor variants resistant to paclitaxel and carboplatin by oncolytic vaccinia virus expressing a CXCR4 borstl

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Factors associated with antimicrobial drug prescription among inpatient dogs and cats at an academic veterinary hospital

Background: Widespread antimicrobial use in dogs and cats drives antimicrobial resistance in both animals and humans.Knowledge of the factors associated with antimicrobial use is limited in veterinary medicine.We examined factors associated with antimicrobial drug prescription among inpatient dogs and cats at an academic veterinary hospital.Methods

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